Journal of Research in Pharmacy Practice

Drug interactions in cancer patients: A hidden risk?

Rachel Riechelmann; Daniel Girardi

Volume 5, Issue 2 , April 2016, Pages 77-78

Abstract

Drug combinations with the potential to interact comprise an important but rather neglected topic in clinical cancer research. While several studies have evaluated drug interactions ... Read More

Editorial

Use of antioxidants in urinary tract infection

Zahra Allameh; Jamshid Salamzadeh

Volume 5, Issue 2 , April 2016, Pages 79-85

Abstract

Pyelonephritis is an inflammatory process, and oxidative stress plays a major role in it. Anti-inflammatory or antioxidant therapy given concomitantly with antibiotics should lower ... Read More

Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: A randomized controlled trial

. Soumya Penala; . Butchibabu Kalakonda; . Krishnajaneya Reddy Pathakota; . Avula Jayakumar; . Pradeep Koppolu; . Bolla Vijaya Lakshmi; . Ruchi Pandey; . Ashank Mishra

Volume 5, Issue 2 , April 2016, Pages 86-93

Abstract

Objective: Periodontitis is known to have multifactorial etiology, involving interplay between environmental, host and microbial factors. The current treatment approaches are ... Read More Objective: Periodontitis is known to have multifactorial etiology, involving interplay between environmental, host and microbial factors. The current treatment approaches are aimed at reducing the pathogenic microorganisms. Administration of beneficial bacteria (probiotics) has emerged as a promising concept in the prevention and treatment of periodontitis. Thus, the aim of the present study is to evaluate the efficacy of the local use of probiotics as an adjunct to scaling and root planing (SRP) in the treatment of patients with chronic periodontitis and halitosis.Methods: This is a randomized, placebo‑controlled, double‑blinded trial involving 32 systemically healthy chronic periodontitis patients. After SRP, the subjects were randomly assigned into the test and control groups. Test group (SRP + probiotics) received subgingival delivery of probiotics and probiotic mouthwash, and control group (SRP + placebo) received subgingival delivery of placebo and placebo mouthwash for 15 days. Plaque index (PI), modified gingival index (MGI), and bleeding index (BI) were assessed at baseline, 1 and 3 months thereafter, whereas probing depth (PD) and clinical attachment level were assessed at baseline and after 3 months. Microbial assessment using N‑benzoyl‑DL‑arginine‑naphthylamide (BANA) and halitosis assessment using organoleptic scores (ORG) was done at baseline, 1 and 3 months.Findings: All the clinical and microbiological parameters were significantly reduced in both groups at the end of the study. Inter‑group comparison of PD reduction (PDR) and clinical attachment gain (CAG) revealed no statistical significance except for PDR in moderate pockets for the test group. Test group has shown statistically significant improvement in PI, MGI, and BI at 3 months compared to control group. Inter‑group comparison revealed a significant reduction in BANA in test group at 1 month. ORG were significantly reduced in test group when compared to control group.Conclusion: Within the limitations of the study, the present investigation showed that the adjunctive use of probiotics offers clinical benefit in terms of pocket depth reduction in moderate pockets and reduced oral malodor parameters.

Effect of high‑dose Ascorbic acid on vasopressor’s requirement in septic shock

. Mohadeseh Hosseini Zabet; . Mostafa Mohammadi; . Masoud Ramezani; . Hossein Khalili

Volume 5, Issue 2 , April 2016, Pages 94-100

Abstract

Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the ... Read More

Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients

. Shahram Taheri; . Ali Asghar Pilehvarian; . Nafiseh Akbari; . Samane Musavi; . Afsoon Emami Naeini

Volume 5, Issue 2 , April 2016, Pages 101-105

Abstract

Objective: Patients on hemodialysis (HD) have a high risk for cardiovascular morbidity and mortality. Cardiac troponins are biomarkers for diagnosing acute myocardial injury ... Read More

Developing a patient satisfaction questionnaire for services provided in Iranian community pharmacies

. Saeed Yaghoubifard; . Arash Rashidian; . Abbas Kebriaeezadeh; . Ali Sheidaei; . Mehdi Varmaghani; . Amir Hashemi-Meshkini; . Hedieh-Sadat Zekri

Volume 5, Issue 2 , April 2016, Pages 106-115

Abstract

Objective: To develop a valid and reliable instrument in the Persian language for evaluating patient satisfaction with services provided in community pharmacies.Methods: We selected ... Read More

Exploring self‑perception of community pharmacists of their professional identity, capabilities, and role expansion

. Anas Mustafa Salim; . Bashir Elgizoli

Volume 5, Issue 2 , April 2016, Pages 116-120

Abstract

Objective: The principal aim of this study was to explore the self‑perception of community pharmacists of their professional identity and roles and how they think patients ... Read More

Self‑medication of irritable bowel syndrome and dyspepsia: How appropriate is it?

. Ramin Niknam; . Sarah Mousavi; . Alireza Safarpour; . Laleh Mahmoudi; . Paria Mahmoudi

Volume 5, Issue 2 , April 2016, Pages 121-125

Abstract

Objective: Self‑medication is common among patients with gastrointestinal (GI) symptoms. This study was performed to evaluate self‑medication among patients who fulfilled ... Read More Objective: Self‑medication is common among patients with gastrointestinal (GI) symptoms. This study was performed to evaluate self‑medication among patients who fulfilled irritable bowel syndrome (IBS) and dyspepsia diagnostic criteria and to investigate the appropriateness of self‑medication with chemical and herbal drugs.Methods: Aprospective, descriptive cross‑sectional study was conducted in outpatient’s GI clinics at Shiraz from November 2011 to May 2012. A GI specialist visited the patients and recruited those who had IBS (base on Rome III adapted criteria) or functional dyspepsia. We surveyed self‑medication among these patients, using a questionnaire containing specific questions about self‑medication.Findings: One thousand four hundred and forty‑seven patients visited by the GI specialist during the study period. Seven hundred and forty‑seven patients had the inclusion criteria, 337 of them fulfilled criteria for IBS, with IBS‑mixed (52%) being the most prevalent subtype, and 410 patients had dyspepsia. Overall, 78.8% of the total participants had recently sought medical attention for their GI complaint. Twenty‑eight percent of patients selected inappropriate medication for their GI complaints. The H2‑blockers class were most common medicines reportedly used. We did not find any significant relationship between age, gender, level of education, marital status, and self‑medication frequency.Conclusion: Patients who fulfilled criteria for IBS had a high tendency to self‑treat their GI symptoms, use of acid‑suppressive agents was common among patients. Around one‑third of patients self‑treated GI symptoms inappropriately. Consequently, the concept of self‑medication among patients has to be revised. We recommend conduction of educational programs to improve self‑medications selection and attitude among patients to reduce the burden on other health care resources.

Pain monitoring and medication assessment in elderly nursing home residents with dementia

. Mette Marie Tang; . Morten Gill Wollsen; . Lise Aagaard

Volume 5, Issue 2 , April 2016, Pages 126-131

Abstract

Objective: To monitor pain intensity, pain symptoms, and medication use in elderly with dementia.Methods: Nursing home residents above 65 years of age, diagnosed with dementia, and ... Read More Objective: To monitor pain intensity, pain symptoms, and medication use in elderly with dementia.Methods: Nursing home residents above 65 years of age, diagnosed with dementia, and showing pain symptoms were included in the study. The patients’ mental status was monitored through a mini‑mental state examination score and observations of pain symptoms using Part 1 of the Mobilization‑Observation‑Behaviour‑Intensity‑Dementia‑2 (MOBID‑2) pain scale. Community pharmacists reviewed the patients’ medication use, and the prescriptions were compared with guidelines for treatment of geriatric patients. Alterations to the patients’ medicine use were forwarded to the general practitioners.Findings: Sixty‑one nursing home residents diagnosed with dementia were identified, 15 of these fulfilled the inclusion criteria, and 12 agreed to participate in the study. The mean age was 87 years of age (range: 77–96), and 42% of the residents were males. The patients’ overall pain intensity was 83% for observations on the numeric pain rating scale (NRS) >0 and 67% for NRS ≥3. Most painful were the situations in which the residents were to mobilize their legs, turn around to both sides of the bed, and when sitting on the bed. The medication reviews identified a total of 95 individual prescriptions, and 33% of these were for nervous system medications, followed by medicines for the treatment of alimentary tract and metabolism disorders (31% of total). Eleven prescriptions for pain medicine were identified; the majority of these were for paracetamol and opioids. Seventeen proposals to patients’ medication use were suggested, but the general practitioners accepted only 6% of these.Conclusion: This study indicates that the MOBID‑2 pain scale in combination with medication reviews can be used as a tool for optimization of patients’ medication use. However, we recommend the conduction of a larger‑scale study in multiple settings, to validate our results and the generalizability of the findings.

Role of pharmacist counseling in pharmacotherapy quality improvement

. Yalda Sanii; . Hassan Torkamandi; . Kheirollah Gholami; . Naser Hadavand; . Mohammadreza Javadi

Volume 5, Issue 2 , April 2016, Pages 132-137

Abstract

Objective: Hospitalization and subsequent discharge home often involve discontinuity of care, multiple changes in medication regimens, and inadequate patient education regarding ... Read More

Attachment to stress ulcer prophylaxis guideline in the neurology wards of two teaching and non-teaching hospitals: A retrospective survey in Iran

. Farzaneh Foroughinia; . Mohammad Madhooshi

Volume 5, Issue 2 , April 2016, Pages 138-141

Abstract

Objective: In this study, we aimed to evaluate the attachment to stress ulcer prophylaxis (SUP) guideline in the neurology wards of two teaching and nonteaching hospitals.Methods: ... Read More

Pharmacy impact on medication reconciliation in the medical intensive care unit

. Brittany M. Wills; . William Darko; . Robert Seabury; . Luke A. Probst; . Christopher D. Miller; . Gregory M. Cwikla

Volume 5, Issue 2 , April 2016, Pages 142-145

Abstract

Objective: Pharmacy‑driven medication history (MH) programs have been shown to reduce the number of serious or potentially life‑threatening (S/PLT) medication discrepancies ... Read More

Captopril‑induced sialadenitis in a patient with end‑stage renal disease

. Fatemeh Musavi Mahdiabadi; . Naemeh Nikvarz

Volume 5, Issue 2 , April 2016, Pages 146-148

Abstract

Sialadenitis is a rare adverse effect of captopril. We report a case of captopril‑induced sialadenitis in a patient with end‑stage renal disease (ESRD). A 20‑year‑old man ... Read More

Volume 11 (2022)

Volume 10 (2021)

Volume 9 (2020)

Volume 8 (2019)

Volume 7 (2018)

Volume 6 (2017)

Volume 5 (2016)

Volume 4 (2015)

Volume 3 (2014)

Volume 2 (2013)

Volume 1 (2012)

Volume & Issue: Volume 5, Issue 2, April 2016, Pages 77-148

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