Journal of Research in Pharmacy Practice

Objective: Pharmacists have a remarkable role in rational use of drugs by dissemination of drug information to guide patients, physicians, and policy makers. The present study ... Read More

Comparison of Gabapentin with Estrogen for treatment of hot flashes in post‑menopausal women

. Zahra Allameh; . Safoura Rouholamin; . Sonia Valaie

Volume 2, Issue 2 , April 2013, Pages 64-69

Abstract

Objective: Various non‑hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective ... Read More Objective: Various non‑hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well‑tolerated treatment modality. The aim of this study was to evaluate whether the treatment with gabapentin is effective in reducing hot flash frequency and severity and also to compare gabapentin 100 mg/day, 300 mg/day and conjugated estrogen in this regards.Methods: In this comparative clinical trial, 100 post‑menopausal women attending outpatient clinics of Isfahan University hospitals were included from April 2008 to February 2009. Participants randomly received gabapentin 300 mg/day, gabapentin 100 mg/day, or conjugated estrogen 0.625 mg/day for 12 weeks. Frequency and severity of hot flashes and adverse effects were compared among the three groups.Findings: From all, 16 participants dropped out. There were no significant differences among the groups before intervention in terms of age, body mass index and baseline hot flash frequency and severity. Hot flash diaries were used to record the frequency and severity of hot flashes. After the treatment period, there was a significant decrease in both severity and frequency of hot flashes in all three groups. Post‑hoc analyses showed that the frequency and severity of hot flashes were significantly lower in those who received gabapentin 300 mg/day or estrogen 0.625 mg/day compared to those who received gabapentin 100 mg/day. There was not statistically significant difference between those who received gabapentin 300 mg/day and those who received estrogen. Very few adverse effects, mostly gastrointestinal discomfort were observed in both gabapentin groups (8%).Conclusion: Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses.

Antibiotic sensitivity pattern and cost-effectiveness analysis of antibiotic therapy in an Indian tertiary care teaching hospital

. Shamungum Sriram; . Varghese Aiswaria; . Annie Eapen Cijo; . Thekkinkattil Mohankumar

Volume 2, Issue 2 , April 2013, Pages 70-74

Abstract

Objective: The purpose of this study is to analyze the antibiotic sensitivity pattern of microorganisms, to study the antibiotic usage pattern, and to conduct a cost‑effectiveness analysis ... Read More

Remifentanil for endotracheal intubation in premature infants: A randomized controlled trial

. Zohreh Badiee; . Mazyar Vakiliamini; . Majid Mohammadizadeh

Volume 2, Issue 2 , April 2013, Pages 75-82

Abstract

Objective: Endotracheal intubation is a common procedure in neonatal care. The objective of this study was to determine whether the premedication with remifentanil before intubation has ... Read More

Pharmaceutical care and medication adherence in management of psychosis in a Nigerian tertiary hospital

. Jonathan Danladi; . Kakjing D. Falang; . Raymond A. Barde; . Nanlok S. Jimam; . Dauda A. Dangiwa; . Hafsat O. Jimoh

Volume 2, Issue 2 , April 2013, Pages 83-87

Abstract

Objective: The primary objective of this study is to examine the medication adherence levels (as a function of pharmaceutical care) and its contributing factors in schizophrenic patients ... Read More

The efficacy of Punica granatum extract in the management of recurrent aphthous stomatitis

. Parichehr Ghalayani; . Behzad Zolfaghary; . Ali Reza Farhad; . Atefeh Tavangar; . Bahram Soleymani

Volume 2, Issue 2 , April 2013, Pages 88-92

Abstract

Objective: Recurrent aphthous stomatitis (RAS) is a common, painful ulcerative disorder of the oral cavity with unknown etiology. No documented cure exists and topical application of ... Read More

Side effects reported by European consumers for medications for erectile dysfunction

. Lise Aagaard; . Ebba Holme Hansen

Volume 2, Issue 2 , April 2013, Pages 93-95

Abstract

Objective: To characterise consumer adverse drug reaction (ADR) reports for phosphodiesterase type 5 (PDE5) inhibitors.Methods: We included ADR reports submitted by adults to the ... Read More

Fluoxetine in the treatment of irritable bowel syndrome

. Forugh Ghaedi

Volume 2, Issue 2 , April 2013, Pages 96-96

Journal of Research in Pharmacy Practice

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Volume & Issue: Volume 2, Issue 2, April 2013

A survey on the factors influencing the pattern of medicine’s use: Concerns on irrational use of drugs

Abstract

Comparison of Gabapentin with Estrogen for treatment of hot flashes in post‑menopausal women

Abstract

Antibiotic sensitivity pattern and cost-effectiveness analysis of antibiotic therapy in an Indian tertiary care teaching hospital

Abstract

Remifentanil for endotracheal intubation in premature infants: A randomized controlled trial

Abstract

Pharmaceutical care and medication adherence in management of psychosis in a Nigerian tertiary hospital

Abstract

The efficacy of Punica granatum extract in the management of recurrent aphthous stomatitis

Abstract

Side effects reported by European consumers for medications for erectile dysfunction

Abstract

Fluoxetine in the treatment of irritable bowel syndrome

Abstract