Document Type : Original Article
Authors
- . Parichehr Ghalayani 1
- . Behzad Zolfaghary 2
- . Ali Reza Farhad 3
- . Atefeh Tavangar 1
- . Bahram Soleymani 4
1 Department of Oral Medicine and Torabinejad Dental Research Center, Isfahan University of Medical Science, Isfahan, Iran
2 Depatment of Pharmacognosy, Isfahan University of Medical Science, Isfahan, Iran
3 Department of Endodontics and Torabinejad Dental Research Center, Isfahan University of Medical Science, Isfahan, Iran
4 Department of Health, Islamic Azad University, Najafabad Branch, Isfahan, Iran
Abstract
Objective: Recurrent aphthous stomatitis (RAS) is a common, painful ulcerative disorder
of the oral cavity with unknown etiology. No documented cure exists and topical application
of medications aims to reduce pain associated with this condition. The aim of this study was
to evaluate the efficacy of Punica granatum (PG) extract on the clinical management of RAS.
Methods: A total of 40 patients with RAS participated in this randomized, double‑blind, and
placebo‑controlled study. During three episodes of RAS, the efficacy of topical PG gel (10%)
was evaluated. Patients were randomly assigned to use placebo gel or PG gel daily. The time
of pain elimination and the time of complete healing were recorded and the pain degree was
assessed and recorded by each patients in different time intervals including: Before using
the oral gel (day 0), and on days 1, 3, 5, 7 after using the product. Data were analyzed using
the repeated measures ANOVA, paired and independent t‑test.
Findings: Mean time of pain elimination showed a significant difference (P < 0.001) between
PG group (3.4 ± 1.09) and placebo group (5.9 ± 0.6). The mean duration of complete healing
also showed a significant difference (P < 0.001) between PG group (5.3 ± 0.81) and placebo
group (8.6 ± 0.99). The visual analog scale score in PG group was significantly less than the
placebo group in all time intervals (day 1 to day 7) (P < 0.001).
Conclusion: The findings of this study revealed that PG extract in the form of oral gel (10%)
may be beneficial in reducing RAS pain and has a positive effect in reducing the overall time
period of complete healing. It was concluded that PG is an effective herbal medicine for
the management of RAS.
Keywords
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