Journal of Research in Pharmacy Practice

Drug reaction with eosinophilia and systemic symptoms syndrome associated with Nitrofurantoin

Authors

. Jitendra Singh 1
. Anju Dinkar 2
. Virendra Atam 1
. Kamlesh K. Gupta 1
. Krishna Kumar Sahani 1

1 Department of Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India

2 Department of Microbiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh, India

Abstract
Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse 
drug‑induced reaction with a prolonged latency period which is characterized by a variety 
of clinical manifestations, usually fever, rash, lymphadenopathy, eosinophilia, and a wide 
range of mild‑to‑severe systemic presentations. Drugs are an important cause of DRESS in 
most of the cases. It is challenging to diagnose DRESS because of the diversity of cutaneous 
eruption and visceral organs involvement. We hereby report a 34‑year‑old female who 
developed DRESS syndrome following ingestion of nitrofurantoin for the treatment of 
urinary tract infection. She was managed conservatively and recovered after few weeks. 
Our aim of this study is to raise awareness to suspect DRESS syndrome in patients who 
present with unusual clinical features with skin involvement after initiating any drug.

Keywords

Drug reaction
drug reaction with eosinophilia and systemic symptom  syndrome
eosinophilia
Nitrofurantoin
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Journal of Research in Pharmacy Practice
Volume 5, Issue 1
Winter 2016
Pages 70-73

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