Document Type : Original Article
Authors
- . Azim Honarmand 1
- . Mohammadreza Safavi 1
- . Mansoureh Chegeni 1
- . Anahita Hirmanpour 1
- . Masoud Nazem 2
- . Seyyad Hamid Sarizdi 1
1 Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences Isfahan, Iran
2 Department of Peadiatric Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Objective: The purpose of the present study was to evaluate the efficacy of
midazolam‑ondansetron combination in prevention of postoperative nausea and
vomiting (PONV) after middle ear surgery and its comparison with using midazolam
or ondansetron alone.
Methods: One hundred and forty patients were enrolled in four groups to receive
midazolam 0.75 mg/kg in group M, ondansetron 4 mg in group O, midazolam 0.75 mg/
kg and ondansetron 4 mg in group MO, and saline 0.9% in group S intravenously just
before anesthesia. Assessment of nausea, vomiting, rescue antiemetic, and side effects
of study drugs such as headache and dizziness was carried out postoperatively for 24 h.
Findings: The incidence of PONV was significantly smaller in groupMO than groupM and
groupO, while there was no significant difference between group M and groupO during
the first 24 h postoperatively. Requirement to the additional antiemetic was significantly
more in group S (71.4%) compared to other groups, while in group MO (11.4%) was
lower than group M (31.4%) and group O (34.3%).
Conclusion: Our study showed that prophylactic administration of midazolam
0.75 mg/kg combined with ondansetron 4 mg was more effective than using midazolam
or ondansetron alone in prevention of PONV after middle ear surgery.
Keywords
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