Journal of Research in Pharmacy Practice

A review of Vitamin D effects on common respiratory diseases: Asthma, chronic obstructive pulmonary disease, and tuberculosis

Authors

. Mohammad Esmaeil Hejazi 1
. Faezeh Modarresi-Ghazani 2
. Taher Entezari-Maleki 2

1 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract
Despite the classic role of Vitamin D in skeletal health, new aspects of Vitamin D have been 
discovered in tissues and organs other than bones. Epidemiological and observational 
studies demonstrate a link between Vitamin D deficiency and risk of developing 
respiratory diseases including asthma, chronic obstructive pulmonary disease(COPD), and 
tuberculosis (TB). To review the literature, we searched the terms “Vitamin D”(using the 
set operator) and “asthma,” “COPD” and “TB” in electronic databases, including PubMed/
MEDLINE, Scopus, and Google Scholar until July 2015. Non‑English articles or articles with 
unavailable full text were excluded. Both in vivo and in vitro studies were included. All the 
reviewed articles state that Vitamin D deficiency is very common among patients with 
respiratory diseases. The present data regarding Vitamin D and asthma is still controversial, 
but data about COPD and TB are more encouraging. The relevant studies have been 
conducted in different populations therefore it is not particularly possible to compare the 
data due to genetic variations. In order to point out a role for Vitamin D, large clinical trials 
with Vitamin D deficient subjects and sufficient Vitamin D supplementation are needed.

Keywords

Asthma
chronic obstructive pulmonary diseases
respiratory diseases
  tuberculosis
Vitamin D
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Journal of Research in Pharmacy Practice
Volume 5, Issue 1
Winter 2016
Pages 7-15

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