Document Type : Original Article
Authors
Abstract
Objective: Laryngoscopy and intratracheal intubation may cause acute hemodynamic
instabilities due to catecholamine release. Magnesium sulfate (MgSO4
) prevents catecholamine
release and results in bradycardia and vasodilatation, so can be used to diminish complications
of laryngoscopy and intubation in doses > 50 mg/kg. The aim of this study was to compare
the different doses of MgSO4
used to improve cardiovascular instabilities due to laryngoscopy
and intratracheal intubation.
Methods: In this double-blind randomized controlled trial, 120 patients undergoing elective
surgery were divided equally into four groups (n = 30) and received different doses of
MgSO4
as case groups (Group I: 30 mg/kg, Group II: 40 mg/kg, Group III: 50 mg/kg) or the
equal volume of normal saline as a control group. The patients’ hemodynamic status was
recorded at baseline, before laryngoscopy and in 1, 3, 5, and 10 minutes after laryngoscopy.
Bradycardia, tachycardia, hypertension, hypotension, ST-T changes, arrhythmias, and duration
of extubation and laryngoscopy were also recorded.
Findings: There was no significant difference in heart rate between four groups(Pbaseline = 0.46,
Ppreoperation = 0.55, P1 min = 0.86, P3 min = 0.30, P5 min = 0.63, P10 min = 0.74). Systolic, diastolic and
mean arterial pressures were statistically significant less at 1, 3, and 5 minutes after intubation
in comparison with other times of following-up in the three groups received MgSO4
than
the control group.
Conclusion: The use of MgSO4
in doses less than 50 mg/kg can be effective to reduce
cardiovascular instability related to laryngoscopy and tracheal intubation.
Keywords
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