Document Type : Original Article
Authors
- . Anahita Hirmanpour
- . Mohammadreza Safavi
- . Azim Honarmand
- . Akram Zavaran Hosseini
- . Maryam Sepehrian
Abstract
Objective: Pruritus is a common and disturbing side effect of neuraxial opioids after
cesarean section. The purpose of this study was to compare the efficacy of intravenous
ondansetron and sub-hypnotic dose of propofol in control and treatment of intrathecal
sufentanil induced pruritus in cesarean surgery.
Methods: Totally, 90 parturient with American Society of Anesthesiology physical status
grade I-II, undergoing spinal anesthesia with 2.5 µg sufentanil and 10 mg bupivacaine 0.5% were
enrolled to this randomized, prospective, double-blind study. The women were randomly
assigned to two groups who received 8 mg ondansetron or 10 mg propofol to treat pruritus
grade ≥3. The patient was evaluated after 5 min and in the lack of successful treatment,
the doses of two drugs repeated and if the pruritus is on-going, the exact treatment with
naloxone was done.
Findings: The incidence of pruritus was 69.3%. Both groups were well-matched. The
peak time pruritus was 30–75 min after injection. The percentage of individuals consumed
naloxone were 6.8% and 15.9% in ondansetron and propofol groups, respectively (P = 0.18).
The mean score of satisfaction (according to visual analog scale criteria) was 9.09 ± 1.1 in
ondansetron group and 9.3 ± 1.07 in the propofol group (P = 0.39).
Conclusion: Ondansetrone and sub-hypnotic dose of propofol are both safe and
well‑tolerated. Due to their same efficacy in the treatment of intrathecal sufentanil‑induced
pruritus, they can be widely used in clinical practice.
Keywords
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