Document Type : Original Article
Authors
Department of Anesthesia and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Objective: Oxytocin routinely used as an uterotonic drug in cesarean delivery. Clothing
problems, adverse effects on fibrinogen and bleeding were presented as side effects of
oxytocin. In in vivo investigation, modest hypercoagulable state was suggested as a side effect
for infusion of oxytocin in parturients. In this study, effects of two different infusion rates of
oxytocin on coagulation of parturient were evaluated during cesarean delivery.
Methods: In a randomized double‑blinded clinical trial, 84 healthy parturient in two equal
groups took oxytocin infusion with the rate of 15 IU/h (Group A) or 30 IU/h (Group B),
after the umbilical cord clamping. Coagulation status measured 30 min after beginning of
infusion by thromboelastography. Data were analyzed by χ2
, paired sample test and ANOVA
considering as significant at P < 0.05.
Findings: The mean (standard deviation) of variables in GroupsA and B were 2.4024 (0.86)
and 2.0429 (0.68) for K (kinetics of clot development), 55.4429 (11.30) and 60.7595 (10.41)
for α (speed of clot strengthening) and 59.779 (19.15) and 70.61 (11.30) for maximum
amplitude (maximum clot strength), respectively. The P values for these variables were 0.036,
0.028 and <0.001, respectively; these changes are consistent with increasing coagulability.
Other measures did not have significant differences.
Conclusion: This in vivo investigation clarified that increasing infusion rate of oxytocin to
30 IU/h can augment coagulability in term parturients.
Keywords
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