Authors

1 Department of Clinical Pharmacy, KSMC, Riyadh, Saudi Arabia

2 Department of Pharmacology, College of Pharmacy, Al-Maarefa University, Riyadh, Saudi Arabia

3 Department of Pharmaceutical Care Services, KSMC, Riyadh, Saudi Arabia

4 Department of Inpatient Pharmacies, KSMC, Riyadh, Saudi Arabia

Abstract

Objective: This study was designed to evaluate the extent of inappropriate utilization 
of intravenous proton‑pump inhibitors (IV‑PPIs) and its financial burden in a Middle 
Eastern tertiary care university hospital. Methods: This was an observational, 
retrospective, cross-sectional study carried out in King Saud University Medical 
City, Riyadh, Saudi Arabia. During a study period of 6 consecutive weeks, all 
hospitalized adult patients (age ≥18) who received IV‑PPI selected and mapped 
with their indications. The patient indications analyzed in comparison with the 
appropriate indications developed based on the evidence from published literature 
and guidelines. Findings: A total of 347 patients were identified, with a mean age 
of 51.5 years, of which 51.9% were male. Of all the patients who received IV-PPIs, 
251 (72.3%), 66 (19%), and 30 (8.7%) received for stress ulcer prophylaxis (SUP), 
peptic ulcer disease (PUD) or gastroesophageal reflux diseases (GERDs), and upper 
gastrointestinal bleeding, respectively. Overall, only 110 (31.7%) of the 347 patients 
received IV-PPIs appropriately. The patients with SUP showed the highest percentage 
of inappropriate use of IV-PPI (80.59%) compared to PUD/GERD (19%). The total 
cost of inappropriate prescription of IV-PPI was 585,167 Saudi Riyal (SAR) (156,044 
USD). Conclusion: There is a high tendency of IV-PPI’s inappropriate prescription 
in our hospital setting. This large-scale inappropriate prescription of IV-PPI in the 
hospital setting not only may lead to increased financial burden but also expose 
patients to number of undesired effects.

Keywords


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