Document Type : Original Article

Authors

Clinical Pharmacy Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

Abstract

Objective: The treatment of hypertension requires special attention because of 
comorbidities and polypharmacy. In a previous study, polypharmacy has been 
associated with a high risk of drug-related problems (DRPs). This study aimed 
to analyze DRPs in Indonesian hypertensive patients focusing on drug therapy 
effectiveness and adverse drug reactions. Methods: A cross-sectional study was 
conducted using medical records’ data, prescriptions, and nursing records to observe 
DRPs that occurred in outpatients with hypertension from February to April 2019. 
A total of 114 outpatients aged ≥23 years with a primary diagnosis of primary 
hypertension were included in this study. DRPs were reviewed based on literature, 
recent guidelines, and drug interaction software. Classification DRPs were done 
using Indonesian-translated Pharmaceutical Care Network Europe V6.02. The data 
obtained were analyzed using univariate descriptive analysis. Findings: Of all 
participants, 65 (57%) outpatients were found to have DRPs related to treatment 
effectiveness (54 cases) and adverse drug reactions (36 cases). The primary cause 
of the problems was an inappropriate drug (94.14%) and dose selection (2.86%). 
Potential drug interactions were found high (62.14%) in the combination of an 
antihypertensive agent with other drugs among patients. Overprescribing drugs 
without clear indications, untreated indications, and subtherapeutic dosage were 
also reported in this study. Conclusion: A significant percentage of outpatients 
being treated for hypertension experienced DRPs. The role of clinical pharmacists 
and physicians in monitoring drug therapy needs to be prioritized to prevent and 
resolve DRPs in outpatients with hypertension.

Keywords

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