Document Type : Original Article
Authors
- . Faezeh Rabbani 1
- . Mohsen Raeisi 2
- . Majid Keivanfar 2
- . Ali Saffaei 3
- . Ali Mohammad Sabzghabaee 4
1 1 Pharmacy Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pediatric Pulmonology, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Objective: We aimed to evaluate the efficacy of an oral combined tablet of
Glycyrrhiza glabra, Viola odorata, and Operculina turpethum (Anti-Asthma®) as
an add-on therapy for the relief of the severity of symptoms in mild-to-moderate
childhood asthma. Methods: This randomized placebo-controlled clinical trial
was performed on 60 children and adolescents with chronic mild-to-moderate
childhood asthma. Patients were randomly divided into cases who received
Anti-Asthma® oral combined tablets 2 tablets twice dailt for 1 month and controls,
received placebo tablets identically the same to Anti-Asthma® (2 tablets, twice
daily, for 1 month) as add-ons to their standard therapy according to the guideline.
The severity and frequency of cough attacks and shortness of breath, respiratory
test indices (based on spirometry), and the extent of disease control and treatment
adherence were measured clinically by validated questionnaires at the beginning
and after the study. Findings: Respiratory test indices improved and the severity
of activity restriction decreased significantly in the cases compared to the controls
However, the mean difference before and after the study was significantly different
between the cases and controls only for the number and severity of coughs and the
severity of activity restriction. In the scores of the Asthma Control Questionnaire,
the cases group had a significant improvement compared to the controls.
Conclusion: Anti-Asthma® oral formulation may be effective as an adjunct add-on
treatment in the maintenance therapy of mild-to-moderate childhood asthma.
Keywords
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