Document Type : Original Article
Authors
- . Jaspreet Kaur Sidhu 1
- . Kiran Jakhar 2
- . Deepti Chopra 3
- . Aditi Dhote 1
- . Vishakha Babber 4
- . Mohammad Shadman 4
- . C. D. Tripathi 1
1 Department of Pharmacology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
2 Department of Psychiatry, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
3 Department of Pharmacology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India
4 Third Year MBBS Student, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
Abstract
Objective: Psychiatric disorders are chronic in nature which require medications
for a long duration. These medications have been associated with many adverse
events. Failure to recognize an adverse drug reaction (ADR) exposes the patient
to continuing risk of ADR, leading to a significant impact on patient’s quality of
life. Thus, the present study carried out to identify the pattern of ADRs reported
due to psychotropic medication. Methods: This was a cross-sectional study
conducted to analyze ADRs reported from the psychiatry department of a tertiary
care teaching hospital from October 2021 to March 2022. Findings: A total of
137 ADRs were identified from 102 patients. Majority of the ADRs were reported
from antidepressants, with paroxetine being the leading offending drug. The
central nervous system was most commonly affected, and dizziness (13.13%)
was the most common ADR noted. On causality assessment, 97 ADRs (70.8%)
were of “possible” type. Almost half of the patients with ADRs (47.5%) recovered
spontaneously. No ADR encountered turned out to be fatal. Conclusion: The
present study revealed that the majority of ADRs reported from psychiatry OPD
were mild in nature. We reinforce the identification of ADR is crucial in the
hospital setting process as it gives an insight into the risk‑benefit ratio for rational
use of the drug.
Keywords
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