Journal of Research in Pharmacy Practice

Dapsone‑induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management

Authors

. Kamal Kumar Sawlani 1
. Shyam Chand Chaudhary 1
. Jitendra Singh 1
. Deep Chandh Raja 1
. Sanjay Mishra 2
. Madhu Mati Goel 3

1 Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India

2 Department of Clinical Hematology and Oncology, King George Medical University, Lucknow, Uttar Pradesh, India

3 Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India

Abstract
Dapsone (4,4’‑diaminodiphenylsulfone) is the parent compound of the sulfones, and it 
has potent antiparasitic, anti‑inflammatory, and immunomodulatory effects. It is used 
in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent 
Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim 
with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure 
red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. 
Patient had an excellent response to corticosteroids after withdrawal of dapsone.

Keywords

Cholestatic jaundice
Dapsone
dermatitis herpetiformis
pure red cell  aplasia
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Journal of Research in Pharmacy Practice
Volume 5, Issue 3
Summer 2016
Pages 215-218

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