Authors
- . Mandana Moradi Dirin 1
- . Sarah Mousavi 2
- . Amir Reza Afshari 1
- . Kaveh Tabrizian 3
- . Mohammad Hossein Ashraf 1
1 Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2 Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pharmacology and Toxicology, Zabol University of Medical Sciences, Zabol, Iran
Abstract
Objective: This study aim to evaluate and compare type and prevalence of drug‑drug
interactions (DDIs) in prescriptions dispensed in both community and hospital setting in
Zabol, Iran.
Methods: A total of 2796 prescriptions were collected from community and inpatient and
outpatient pharmacy of Amir‑al‑momenin only current acting hospital in Zabol, Iran. The
prescriptions were processed using Lexi‑Comp drug interaction software. The identified
DDIs were categorized into five classes (A, B, C, D, X).
Findings: Overall 41.6% of prescriptions had at last one potential DDI. The most common
type of interactions was type C (66%). The percentage of drug interactions in community
pharmacies were significantly lower than hospital pharmacies (P < 0.0001).
Conclusion: Our results indicate that patients in Zabol are at high risk of adverse drug
reactions caused by medications due to potential DDIs. Appropriate education for physicians
about potentially harmful DDIs, as well as active participation of pharmacists in detection
and prevention of drug‑related injuries, could considerably prevent the consequence of
DDIs among patients.
Keywords
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