1 Pharmacy Students’ Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Medical Students’ Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


Objective: Methamphetamine is the second most widely abused drug worldwide. We 
performed a study on the treatment outcome of acute methamphetamine intoxication in 
a referral tertiary care University hospital in Iran.
Methods: In this hospital‑based, retrospective study which was carried out from 2012 to 
2013, medical records of all patients aged 18 to 65 years who were admitted with a reliable 
history and clinical diagnosis of acute methamphetamine intoxication were abstracted 
and analyzed. Patients’ data included gender, age, type and route of poisoning, clinical 
manifestations, duration of hospitalization, and the treatment outcome. ANOVA, Chi‑square, 
and binary logistic regression statistical tests were used for data analysis.
Findings: A total of 129 patients with a mean age of 30.70 ± 0.93 (mean ± standard error), 
including 111 (86%) males, had been fully evaluated. Most of the patients had intentional 
poisoning (93.7%). In 42.6% of patients, inhalation was the main route of exposure. Most of the 
patients had complete improvement without any complication (89.1%). Age (odds ratio [OR], 
1.05; 95% confidence interval [95% CI] 1.006–1.099), suicide history (OR, 30.33; 95% CI 
3.11–295.24), route of poisoning ([ingestion: OR, 0.21; 95% CI 0.05–0.87], [inhalation: OR, 0.19; 
95% CI 0.04–0.78]), and pulmonary system manifestations (OR 1.84; 95% CI 1.15–2.93) 
were predictive in patients outcome (P < 0.05).
Conclusion: Methamphetamine poisoning was more common in males with intentional 
poisoning. Age, past history of suicide, route of poisoning, and pulmonary manifestations 
on admission could be considered as important predictive factors in patients’ outcome.
Keywords: Methamphetamine; poisoning; treatment outcome

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