Document Type : Original Article
Authors
1 Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Anesthesia and Critical Care, Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Objective: The aim of this study is to compare the effects of hypercapnic hyperventilation
and normocapnic normoventilation on emergence time from propofol and isoflurane
anesthesia.
Methods: In this clinical trial, the differences in emergence time were evaluated in 80 patients
undergoing elective abdominal surgery in Alzahra University hospital, Isfahan, Iran, in 2011-
2012. Patients were randomly divided into four groups (groups 1-4) receiving isoflurane
hypercapnic hyperventilation, isoflurane normocapnic normoventilation, propofol hypercapnic
hyperventilation, and propofol normocapnic normoventilation, respectively. Hypercapnia was
maintained by adding CO2
to the patient’s inspired gas during hyperventilation. The emergence
time and the duration of stay in recovery room in the four groups were measured and
compared by one‑way analysis of variance (ANOVA) and least significant difference tests.
Findings: The average emergence time in groups 1, 2, 3, and 4 were (11.3 ± 3.2), (15.2 ± 3.8),
(9 ± 4.2) and (11.8 ± 5.3) min, respectively. These differences were significant (P = 0.001). In
patients receiving propofol hypercapnic hyperventilation, the emergence time was faster than
in other groups. There was also a significant difference in duration of stay in recovery room
between the groups(P = 0.004). Patients who received isoflurane hypercapnic hyperventilation
had a shortest length of stay in the recovery room.
Conclusion: The emergence time after intravenous anesthesia with propofol can be
shortened significantly by using hyperventilation and hypercapnia, without any side effects.
Keywords
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