Journal of Research in Pharmacy Practice

Chronopharmacodynamics of drugs in toxicological aspects: A short review for clinical pharmacists and pharmacy practitioners

Authors

. Pinar Erkekoglu
. Terken Baydar

Department of Toxicology, Hacettepe University, Ankara, Turkey

Abstract
For many decades, researchers are aware of the importance of circadian rhythm in 
physiological/biochemical properties and drug metabolism. Chronopharmacology is the study 
of how the effects of drugs vary with biological timing and endogenous periodicities. It has 
been attaching substantial attention in the last years. Chronopharmacodynamics mainly deals 
with the biochemical and physiological effects of drugs on the body, the mechanisms of drug 
action, the relationship between drug concentration and effect in relation to circadian clock. 
In this review, we will focus on mammalian circadian pharmacodynamics and discuss new 
chronotherapy approaches. Moreover, we will try to highlight the chronopharmacodynamics 
of cardiovascular drugs, anti‑cancer drugs, analgesics and non‑steroidal anti‑inflammatory 
drugs (NSAIDs) and give some practical concerns for clinical pharmacists and pharmacy 
practitioners, concerning this issue.

Keywords

Analgesics
anti‑cancer drugs
cardiovascular drugs
chronodynamics
  chronopharmacology
circadian rhythm
non‑steroidal anti‑inflammatory drugs
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Journal of Research in Pharmacy Practice
Volume 1, Issue 2
November 2012
Pages 41-47

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