Document Type : Original Article
Authors
Pediatrics Department, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Medication errors (ME) and adverse drug reactions still continue to be the important
factors for out- and in-patient treatments. MEs are critical troubles in all hospitalized
populations that can increase length of hospital stay, expenses, mortality and morbidity. In
many countries, clinical pharmacists have been involved in reducing MEs from years ago.
A growing body of evidence suggests that pharmacist interventions have major impact on
reducing MEs in pediatric patients, thus improving the quality and efficiency of care provided.
This paper presents a literature review on the role of clinical pharmacists in reducing MEs,
and underscores the importance of pharmacist-physician-patient collaboration for all patients
notably in the pediatric age group.
Keywords
- Waldman JD, Smith HL. Strategic planning to reduce medical
errors: Part I−diagnosis. J Med Pract Manage 2012;27:230-6.
2. Kohn LT, Corrigan JM, Donaldson MS To Err is Human:
Building a Safer Health System. Washington, DC: National
Academy Press; 1999.
3. Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP.
Adverse drug events in hospitalized patients. Excess
length of stay, extra costs, and attributable mortality. JAMA
1997;227:301-6.
4. Bates DW, Cullen DJ, Laird N, Petersen LA, Small SD, Servi D,
et al. Incidence of adverse drug events and potential adverse
drug events: Implications for prevention. JAMA 1995;274:29-34.
5. Leape LL, Bates DW, Cullen DJ, Cooper J, Demonaco HJ,
Gallivan T, et al. Systems analysis of adverse drug events.
ADE Prevention Study Group. JAMA 1995;274:35-43.
6. Bates DW, Spell N, Cullen DJ, Burdick E, Laird N, Petersen LA,
et al. The costs of adverse drug events in hospitalized patients.
Adverse Drug Events Prevention Study Group. JAMA
1997;277:307-11.
7. Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape LL.
Relationship between medication errors and adverse drug
events. J Gen Intern Med 1995;10:199-205. - 8. Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR,
Lawthers AG, et al. Incidence of adverse events and negligence
in hospitalized patients: Results of the Harvard Medical
Practice Study I. N Engl J Med 1991;324:370-6.
9. Leape LL, Brennan TA, Laird N, Lawthers AG, Localio AR,
Barnes BA, et al. The nature of adverse events in hospitalized
patients: Results of the Harvard Medical Practice Study II. N
Engl J Med 1991;324:377-84.
10. Cohen V, Jellinek SP, Hatch A, Motov S. Effect of clinical
pharmacists on care in the emergency department: a
systematic review. Am J Health Syst Pharm 2009;66:1353-61.
11. von Laue NC, Schwappach DL, Koeck CM. The epidemiology
of preventable adverse drug events: a review of the literature.
Wien Klin Wochenschr 2003;115:407-15.
12. Klopotowska JE, Kuiper R, van Kan HJ, de Pont AC, Dijkgraaf
MG, Lie-A-Huen L, et al. On-ward participation of a hospital
pharmacist in a Dutch intensive care unit reduces prescribing
errors and related patient harm: An intervention study. Crit
Care 2010;14:R174.
13. Klopotowska JE, Wierenga PC, de Rooij SE, Stuijt CC, Arisz
L, Kuks PF, et al. The effect of an active on-ward participation
of hospital pharmacists in Internal Medicine teams on
preventable Adverse Drug Events in elderly inpatients:
Protocol of the WINGS study (Ward-oriented pharmacy
in newly admitted geriatric seniors). BMC Health Serv Res
2011;11:124.
14. Kunac DL, Reith DM. Identification of priorities for medication
safety in neonatal intensive care. Drug Saf 2005;28:251-61.
15. Folli HL, Poole RL, Benitz WE, Russo JC. Medication error
prevention by clinical pharmacists in two children’s hospitals.
Pediatrics 1987;79:718-22.
16. Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD,
Federico F, et al. Medication errors and adverse drug events
in pediatric inpatients. JAMA 2001;285:2114-20.
17. Ross LM, Wallace J, Paton JY. Medication errors in a pediatric
teaching hospital in the UK: Five years operational experience.
Arch Dis Child 2000;83:492-7.
18. Lowry JA, Vandover JC, DeGreeff J, Scalzo AJ. Unusual
presentation of iatrogenic phenytoin toxicity in a newborn. J
Med Toxicol 2005;1:26-9.
19. Kohn LT, Corrigan JM, Donaldson MS. To Err Is Human.
Washington, DC: National Academy Press; 2000.
20. Yanni S. Disposition and Interaction of Bio therapeutics in
Pediatric Populations. Curr Drug Metab 2012 [In press].
21. Levine SR, Cohen MR, Blanchard NR, Frederico F, Magelli M,
Lomax C, et al. Guidelines for preventing medication errors
in pediatrics. J Pediatr Pharmacol Ther 2001;6:426-42.
22. Kelishadi R, Hashemipour M, Adeli K, Tavakoli N,
Movahedian-Attar A, Shapouri J, et al. Effect of zinc
supplementation on markers of insulin resistance, oxidative
stress, and inflammation among prepubescent children with
metabolic syndrome. Metab Syndr Relat Disord 2010;8:505-10.
23. Rezvanian H, Hashemipour M, Kelishadi R, Tavakoli N,
Poursafa P. A randomized, triple masked, placebo-controlled
clinical trial for controlling childhood obesity. World J Pediatr
2010;6:317-22.
24. Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N,
Amini M, Tavakoli N, et al. Effect of zinc supplementation on
insulin resistance and components of the metabolic syndrome in
pre pubertal obese children. Hormones (Athens) 2009;8:279-85.
25. Rashed AN, Wong IC, Cranswick N, Tomlin S, Rascher W,
Neubert A. Risk factors associated with adverse drug reactions
in hospitalised children: international multicentre study. Eur
J Clin Pharmacol 2012;68:801-10.
26. Matsubara K, Toyama A, Satoh H, Suzuki H, Awaya T, Tasaki Y,
et al. Longer working hours of pharmacists in the ward
resulted in lower medication-related errors−survey of national
university hospitals in Japan. Yakugaku Zasshi 2011;131:635-41.
27. Bond CA, Raehl CL, Franke T. Clinical pharmacy services and
hospital mortality rates. Pharmacotherapy 1999;19:556-64.
28. Leape LL, Cullen DJ, Clapp MD, Burdick E, Demonaco HJ,
Erickson JI, et al. Pharmacist participation on physician rounds
and adverse drug events in the intensive care unit. JAMA
1999;282:267-70.
29. Zhang C, Zhang L, Huang L, Luo R, Wen J. Clinical
pharmacists on medical care of pediatric inpatients: A singlecenter randomized controlled trial. PLoS One 2012;7:e30856.
30. Academic Health Centers. Leading Change in the 21st Century.
Washington, DC: National Academy Press; 2003.
31. Koren G. Trends of medication errors in hospitalized children.
J Clin Pharmacol 2002;42:707-10.
32. Kunac DL, Kennedy J, Austin N, Reith D. Incidence,
preventability, and impact of Adverse Drug Events (ADEs)
and potential ADEs in hospitalized children in New Zealand:
a prospective observational cohort study. Paediatr Drugs
2009;11:153-60.
33. Fernandez-Llamazares CM, Calleja-Hernández MA,
Manrique-Rodríguez S, Pérez-Sanz C, Durán-García E,
Sanjurjo-Sáez M. Prescribing errors intercepted by clinical
pharmacists in paediatrics and obstetrics in a tertiary hospital
in Spain. Eur J Clin Pharmacol 2012 [In Press].
34. Kunac DL, Kennedy J, Austin N, Reith D. Incidence,
preventability, and impact of Adverse Drug Events (ADEs)
and potential ADEs in hospitalized children in New Zealand:
a prospective observational cohort study. Paediatr Drugs
2009;11:153-60.
35. Robinson RF. Hospital pharmacists’ role in the prevention and
management of respiratory syncytial virus. Am J Health Syst
Pharm 2008;65(23 Suppl 8):S20-2.
36. Kennedy MJ, Phan H, Benavides S, Potts A, Sorensen S. The
role of the pediatric pharmacist in personalized medicine
and clinical pharmacogenomics for children: pediatric
pharmacogenomics working group. J Pediatr Pharmacol Ther
2011;16:118-22.
37. Kaushal R, Bates DW, Abramson EL, Soukup JR, Goldmann
DA. Unit-based clinical pharmacists’ prevention of serious
medication errors in pediatric inpatients. Am J Health Syst
Pharm 2008;65:1254-60.
38. Ito S, Nakamura H, Kobayashi T. Pediatric Pharmacology in
Japan. Paediatr Drugs 2012;14:247-9.
39. Leong R, Vieira ML, Zhao P, Mulugeta Y, Lee C, Huang SM,
et al. Regulatory experience with physiologically based
pharmacokinetic modeling for pediatric drug trials. Clin
Pharmacol Ther 2012;91:926-31.
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