Journal of Research in Pharmacy Practice

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

Authors

Zohreh Oghabian
June Williams
Mohammad Mohajeri
Samaneh Nakhaee
Saeedeh Shojaeepour
Alireza Amirabadizadeh
Samira Elhamirad
Morteza Hajihosseini
Borhan Mansouri
Omid Mehrpour
Abstract
The aim of the present study was to evaluate the demographics, clinical characteristics, fatal dose, the efficacy of treatments, and prognosis in paraquat (PQ) poisoning in the Kerman Province of Iran. Methods:This analytical cross-sectional study was conducted on 126 PQ poisoned patients who were referred to Afzalipour Hospital during 2006–2015. Demographic variables such as age and gender, signs and symptoms of poisoning, the estimated ingested dosage of PQ, and clinical outcome were extracted from medical records. Patients were compared and categorized into two groups considering the outcome: survivors and nonsurvivors. Patients with nonoral exposures, combined drug exposures, PQ exposures more than 24 h before the presentation, and critical underlying diseases were not included in the study. Findings: Our results indicated that the mean dose of PQ used by all patients was 2358 mg, which was reported as 1846 and 2812 mg in females and males, respectively. Moreover, the results showed that the highest mortality rate was in patients with respiratory distress, followed by oral ulceration and excess salivation. In all PQ-poisoned patients, the dose of greater than approximately 2250 mg predicted death with 86.2% specificity and 75.7% sensitivity. Conclusion: Based on the results of the present study, the mortality rate in PQ-poisoned patients depended on the dose of poison, blood sugar level, and aspartate transaminase levels. Our results suggest that these parameters have excellent prognostic value for the prediction of mortality.

Keywords

Mortality
paraquat
poisoning
prediction
prognosis
survival
treatment
Journal of Research in Pharmacy Practice
Volume 8, Issue 3
Summer 2019
Pages 129-136

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us