Journal of Research in Pharmacy Practice

Comparative evaluation between the LaxaPlus Barij® and polyethylene glycol (4000) in the pediatric functional constipation in children 2–15 years old

Document Type : Original Article

Authors

Peiman Nasri 1
Shima Saeidi 2
Hosein Saneian 1
Fatemeh Famouri 1
Somayeh Sadeghi 3
Leila Mohammad Taghizadeh Kashani 4
Majid Khademian 1

1 Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

2 Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Department of Traditional Medicine, Medicinal Plants Research Center of Barij, Kashan, Iran

Abstract
Objective: This study aimed to compare the LaxaPlus Barij® and polyethylene glycol (4000) in pediatric (children 2–15 years old) functional constipation. Methods: The present study is a randomized clinical trial. The study population included patients with functional constipation aged 2–15 years who were referred to the gastrointestinal clinic of Imam Hossein hospital in Isfahan in 2019. Patients were randomly assigned into two treatment groups. Data analysis was performed using SPSS software. The significance level in the present study is considered <0.05. Findings: Sixty children with functional constipation were selected based on the inclusion and exclusion criteria in this study. The present study results showed no significant difference between demographic characteristics, including age, weight, and gender of children with constipation in the two groups (P > 0.05). The present study results showed that both groups' mean stool consistency and the number of bowel movements increased significantly after the intervention (P < 0.05). However, the number of bowel movements in the first group was significantly higher than in the second group (P < 0.05). Conclusion: The present study results showed that both drugs effectively treat children with functional constipation. However, after 8 weeks of intervention, the frequency of bowel movements, pain intensity, and abdominal pain in the group LaxaPlus Barij® was more effective. However, the level of satisfaction did not differ significantly between the two groups.

Graphical Abstract

Comparative evaluation between the LaxaPlus Barij® and polyethylene glycol (4000) in the pediatric functional constipation in children 2–15 years old

Keywords

Child
constipation
LaxaPlus Barij®
polyethylene glycol
Journal of Research in Pharmacy Practice
Volume 10, Issue 4
Autumn 2021
Pages 180-184

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