Journal of Research in Pharmacy Practice 4 3 2015 07 01 Effect of Omega-3 fatty acids on blood pressure and serum lipids in continuous ambulatory peritoneal dialysis patients 135 141 30228 EN . Afsoon Emami Naini Department of Internal Medicine, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran . Nooshin Keyvandarian Department of Internal Medicine, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran . Mojgan Mortazavi Department of Internal Medicine, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran . Shahram Taheri Department of Internal Medicine, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran . Sayed Mohsen Hosseini Department of Biostatistics and Epidemiology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Journal Article 2023 03 28 Objective: Hypertension and hyperlipidemia are two major risk factors for cardiovascular disease <br />in continuous ambulatory peritoneal dialysis (CAPD) patients. This study was designed to investigate <br />the effect of omega-3 fatty acids on blood pressure (BP) and serum lipids in CAPD patients.<br />Methods: This study was a randomized double‑blind clinical trial in which 90 CAPD patients <br />were randomly assigned to either the omega‑3 or the placebo group. Patients in omega‑3 <br />group received 3 g/day omega‑3 for 8 weeks, whereas patients in the control group received <br />placebo. At baseline and at the end of 8 weeks, the patients’ BP was controlled, and serum <br />biochemistry was measured.<br />Findings: Mean systolic BP decreased (–22.2 ± 14.2 mmHg) in the omega‑3 group at the end <br />of the study while in the placebo group increased (+0.5 ± 30.2 mmHg) (P < 0.0001). Mean <br />diastolic BP of the omega‑3 group decreased more (–11.95 ± 11.9 mmHg) comparing with <br />the placebo group (–1.1 ± 17.3 mmHg) (P = 0.001). There were no significant differences <br />between the two groups in mean changes in serum triglyceride, and total, high‑density <br />lipoprotein, and low‑density lipoprotein cholesterol.<br />Conclusion: The results of this study indicate that omega‑3 reduced BP significantly but <br />had no effect on lipid profile in our CAPD patients.<br /><br /> https://jrpp.mui.ac.ir/article_30228_e2fd3d57e43d80a5df90a90a0da3bbf8.pdf