The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
Volume 1, Issue 2, November 2012, Pages 77-80
. Farahnaz Fatemi Naini, . Alireza Vaez Shooshtari, . Bahareh Ebrahimi, . Razieh Molaei
Abstract Objective: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered
having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of
this combination in vitiligo.
Methods: This was a pilot randomized, double‑blind, placebo‑controlled trial on 46
symmetrical vitiligo lesions of limbs in 23 patients referring to dermatology clinics,
Isfahan, Iran in 2010. Patients were received this formula or placebo gels for the right
and left lesions. Lesion area and degree of pigmentation were assessed at baseline, 2, 4,
and 6 months.
Findings: There were no significant changes in lesion area and perifollicular pigmentation
in each group (P > 0.05).
Conclusion: The results indicated no significant therapeutic effect for PSD in vitiligo.