Dapsone‑induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
Volume 5, Issue 3, Summer 2016, Pages 215-218
. Kamal Kumar Sawlani, . Shyam Chand Chaudhary, . Jitendra Singh, . Deep Chandh Raja, . Sanjay Mishra, . Madhu Mati Goel
Abstract Dapsone (4,4’‑diaminodiphenylsulfone) is the parent compound of the sulfones, and it
has potent antiparasitic, anti‑inflammatory, and immunomodulatory effects. It is used
in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent
Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim
with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure
red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis.
Patient had an excellent response to corticosteroids after withdrawal of dapsone.