Journal of Research in Pharmacy Practice

A safety evaluation of midazolam use for nasogastric tube placement

Jenna B Wells; David H Murman; Alison L Sullivan

Volume 10, Issue 3 , July 2021, , Pages 144-148

Abstract

Nasogastric tube (NGT) insertion is one of the most painful procedures in the emergency department (ED). A recent study determined that giving intravenous (IV) midazolam before ... Read More

Effect of oral midazolam in pain relief of patients need nasogastric tube insertion: A clinical trial study

Asghar Jafari Rouhi; Alireza Zeraatchi; Farzad Rahmani; Nima Motamed; Ala Rastin; Afsaneh Karami; Arezoo Nejabatian

Volume 9, Issue 2 , April 2020, , Pages 112-117

Abstract

Due to the presence of pain during nasogastric tube (NGT) insertion and related complications and lack of positive clinical response of nasopharyngeal anesthesia with lidocaine ... Read More

Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery

. Azim Honarmand; . Mohammadreza Safavi; . Mansoureh Chegeni; . Anahita Hirmanpour; . Masoud Nazem; . Seyyad Hamid Sarizdi

Volume 5, Issue 1 , January 2016, , Pages 16-21

Abstract

Objective: The purpose of the present study was to evaluate the efficacy of midazolam‑ondansetron combination in prevention of postoperative nausea and vomiting (PONV) after ... Read More

Comparison of the effects of intravenous premedication: Midazolam, Ketamine, and combination of both on reducing anxiety in pediatric patients before general anesthesia

. Parvin Sajedi; . Bashir Habibi

Volume 4, Issue 4 , October 2015, , Pages 187-192

Abstract

Objective: In some medical circumstances, pediatric patients may need premedication for transferring to the operating room. In these situations, using intravenous premedication is ... Read More

The efficacy of different doses of Midazolam added to Lidocaine for upper extremity Bier block on the sensory and motor block characteristics and postoperative pain

. Azim Honarmand; . Mohammadreza Safavi; . Koorosh Nemati; . Padideh Oghab

Volume 4, Issue 3 , July 2015, , Pages 160-166

Abstract

Objective: This study was designed to evaluate the effect of different doses of midazolam on anesthesia and analgesia quality when added to lidocaine during the intravenous regional anesthesia ... Read More

Midazolam premedication for Ketamine-induced emergence phenomenon: A prospective observational study

. Deepa Kameswari Perumal; . Mangaiarkkarasi Adhimoolam; . Nitya Selvaraj; . Suneeth Pullikotil Lazarus; . Meher Ali Raja Mohammed

Volume 4, Issue 2 , April 2015, , Pages 89-93

Abstract

Objective: Ketamine administration is known to induce hemodynamic pressor response and psychomimetic effects which could be attenuated by appropriate premedication. The present ... Read More Objective: Ketamine administration is known to induce hemodynamic pressor response and psychomimetic effects which could be attenuated by appropriate premedication. The present study was designed to evaluate the effect of midazolam on hemodynamic stability and postoperative emergence phenomenon following ketamine anesthesia.Methods: This was a prospective observational study including 30 adult patients with American Society of Anesthesiologists physical grades I and II scheduled for elective short surgeries under ketamine anesthesia. Patients were premedicated with midazolam (0.02 mg/kg intravenously) before the ketamine induction (1 mg/kg intravenously). Demographic data and hemodynamic variables were observed during the perioperative period. Pain score by visual analog scale score and psychomimetic effects were recorded postoperatively.Findings: The mean ± standard deviation of heart rate, systolic blood pressure, diastolic blood pressure, and respiratory rate were decreased postoperatively (85.3 ± 11.4, 120.7 ± 8.2, 79.2 ± 5.5, 13.5 ± 1.8, respectively) compared to intraoperative period (88.53 ± 14.1, 123.83 ± 13.8, 83 ± 9.1, 14.13 ± 2.0, respectively). There was statistically significant decrease in systolic (P = 0.03) and diastolic (P = 0.002) blood pressure, but not with heart rate and respiratory rate. Eighty percent of patients had no pain at ½ hour and 1 hour, while this increased to 90% at 2 hours postoperatively. Mild emergence delirium was noted in 13.3% and 16.7% at ½ hour and 1 hour, respectively, which decreased to 13.3% at 2 hours. Dreams were noticed in 20%, 27% and 10% of patients at ½ hour, 1 and 2 hours after surgery, respectively.Conclusion: Midazolam premedication in ketamine anesthesia effectively attenuated the hemodynamic pressor response and postoperative emergence phenomenon. Hence, the combination of midazolam with ketamine can be safely used for short surgical painful procedures in adults.

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Keywords = Midazolam

A safety evaluation of midazolam use for nasogastric tube placement

Abstract

Effect of oral midazolam in pain relief of patients need nasogastric tube insertion: A clinical trial study

Abstract

Prophylactic antiemetic effects of Midazolam, Ondansetron, and their combination after middle ear surgery

Abstract

Comparison of the effects of intravenous premedication: Midazolam, Ketamine, and combination of both on reducing anxiety in pediatric patients before general anesthesia

Abstract

The efficacy of different doses of Midazolam added to Lidocaine for upper extremity Bier block on the sensory and motor block characteristics and postoperative pain

Abstract

Midazolam premedication for Ketamine-induced emergence phenomenon: A prospective observational study

Abstract