Journal of Research in Pharmacy Practice

Potential of drug interactions as a cause of adverse drug reactions in patients with kidney diseases

Tahereh Gholipur Shahraki; Fatemeh Yari; Shiva Seirafian; Shirinsadat Badri

Volume 9, Issue 2 , April 2020, , Pages 121-124

Abstract

Adverse drug reactions (ADRs) are one of the major causes of mortality. One of the major causes of ADR is drug–drug interactions. The purpose of this study was to evaluate ... Read More

Specific genes associated with adverse events of methylphenidate use in the pediatric population: A systematic literature review

Beinta Joensen; Morten Meyer; Lise Aagaard

Volume 6, Issue 2 , April 2017, , Pages 65-72

Abstract

The aim of this study was to review empirical studies examining associations between candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and adolescents. ... Read More The aim of this study was to review empirical studies examining associations between candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and adolescents. The PubMed, EMBASE, CINAHL, and Web of Science databases were searched from their inception until March 2017. We included empirically based articles on pharmacogenetic studies in 0–17-year-old patients that investigated associations between specific candidate genes, their polymorphisms, and reported AEs. We extracted information about study design, setting, type of AE reporter, studied genes and their polymorphisms, age and gender, administered doses, method of genotyping, outcome measures, and main findings. A total of nine articles reporting information about four double-blind, placebo-controlled, cross-over studies and five open-label cohort studies were eligible for inclusion. Studies were published from 2006 onward and included a total of 998 patients (3–17-year-olds) diagnosed with attention-deficit hyperactivity disorder (ADHD). Studies predominantly involved males and lasted from 1 to 12 weeks. Studies used polymerase chain reaction and single nucleotide polymorphism genotyping methodology. Reported AEs were significantly associated with the following genes: appetite reduction (CES1*G); buccal-lingual movements (T1065G); diastolic blood pressure (ADRA2A Mspl C/C-GC); emotionality (DAT1*9/9); irritability (SNAP25 T1065G); picking (DRD4*7/DRD4*4); social withdrawal (DRD4*7/DRD4*4); somatic complaints (DAT1*10/10); tics (5-HTTLRP*S/L*L/L; SNAP25 T1065G); sadness (CES1*rsl12443580); and vegetative symptoms (5-HTTLPR). In conclusion, only few MPH pediatric pharmacogenetic studies were located, and large between-study heterogeneity was found. Studies were of naturalistic design and of short duration. They included small patient samples, poorly standardized treatment regimens, and limited outcome assessments. In the future, more pharmacogenomic studies in ADHD are needed, preferably using randomized, controlled study designs and of longer duration (more than 6 months).

Pediatric hospital admission due to adverse drug reactions: Report from a tertiary center

. Kheirollah Gholami; . Fatemeh Babaie; . Gloria Shalviri; . Mohammad Reza Javadi; . Toktam Faghihi

Volume 4, Issue 4 , October 2015, , Pages 212-215

Abstract

Objective: Adverse drug reactions (ADRs) are known as a cause of hospital admission. We have carried out a prospective study to characterize and assess the frequency, probability, preventability, ... Read More

A two-year utilization of the pharmacist-operated drug information center in Iran

. Taher Entezari‑Maleki; . Mohammad Taraz; . Mohammad Reza Javadi; . Mir Hamed Hajimiri; . Kaeh Eslami; . Iman Karimzadeh; . Maysam Esmaeili; . Kheirollah Gholami

Volume 3, Issue 4 , October 2014, , Pages 116-122

Abstract

Objective: To assess and describe the call services delivered by drug and poison information call center (DPIC) of 13‑Aban pharmacy, which is closely operated by the Department ... Read More

Identification and management of adverse effects of antipsychotics in a tertiary care teaching hospital

. Jisha Myalil Lucca; . Ramesh Madhan; . Gurumurthy Parthasarathi; . Dushad Ram

Volume 3, Issue 2 , April 2014, , Pages 46-50

Abstract

Objective: Antipsychotics have revolutionized psychiatry by allowing significant numbers of patients in long‑term hospital settings to be discharged and successfully maintained ... Read More

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Keywords = Adverse drug reaction

Potential of drug interactions as a cause of adverse drug reactions in patients with kidney diseases

Abstract

Specific genes associated with adverse events of methylphenidate use in the pediatric population: A systematic literature review

Abstract

Pediatric hospital admission due to adverse drug reactions: Report from a tertiary center

Abstract

A two-year utilization of the pharmacist-operated drug information center in Iran

Abstract

Identification and management of adverse effects of antipsychotics in a tertiary care teaching hospital

Abstract