Journal of Research in Pharmacy Practice

Statin type and cancer outcomes in patients with diabetes type 2 and solid tumors

Alice C Ceacareanu; Shanria D Jolly; George K Nimako; Zachary A. P. Wintrob

Volume 10, Issue 1 , January 2021, , Pages 50-56

Abstract

Type 2 diabetes mellitus (T2DM) affects 10% of Americans and is associated with an increased incidence of cancer. Statins are first-line cholesterol-lowering medications in the ... Read More

Effect of pharmacist intervention on medication adherence and clinical outcomes of type 2 diabetes mellitus outpatients in primary healthcare in Indonesia

Nani Apriani Besemah; Ratu Ayu Dewi Sartika; Rani Sauriasari

Volume 9, Issue 4 , October 2020, , Pages 186-195

Abstract

In Indonesia, the role of pharmacists in primary healthcare is still very limited or even absent. This study evaluates the effectiveness of programs delivered for type 2 diabetes mellitus ... Read More In Indonesia, the role of pharmacists in primary healthcare is still very limited or even absent. This study evaluates the effectiveness of programs delivered for type 2 diabetes mellitus (T2DM) patients by pharmacists in primary healthcare through counseling, short message service (SMS) reminders, and medication booklets. Methods: A quasi-experimental study with a pretest–posttest design was conducted from April to August 2018 at Merdeka and Dempo primary health-care centers, Palembang, South Sumatra Province, Indonesia. Counseling and medication booklets were distributed three times during the study period, while SMS reminders were sent once a week. Counseling was given for the management of diabetes mellitus (DM), including during the Ramadan fasting period, together with management for acute and chronic complications. The medication adherence level was measured using a medication adherence questionnaire (MAQ) and pill count adherence (PCA). The study sample comprised 80 T2DM patients, who were allocated into either the control group (CG) (n = 40) or intervention group (IG) (n = 40). Clinical outcomes were determined by measuring glycated hemoglobin (HbA1c), blood pressure, and lipid profiles. Findings: After the intervention, the IG showed significant improvements in most parameters, except for high-density lipoprotein cholesterol and systolic and diastolic blood pressure. HbA1c levels were reduced, while MAQ scores and PCA scores were improved. Lipid parameters were significantly reduced total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and triglyceride (TG). Compared with the CG, most parameters were significantly improved in the IG. Pharmacist counseling significantly improved almost all clinical parameters (HbA1c, TC, LDL-c, and TG). Pharmacist counseling was 7.1 times greater in lowering HbA1c compared with no counseling, after adjusted by other variables. The variable that most influenced the lowering of HbA1c was infrequent (“not often”) consumption of unhealthy foods (OR 14.9; 95% CI 3.5-63.7). Conclusion: The pharmacist primary health-care intervention program implemented in this study significantly improved HbA1c, TC, LDL-c, TG, and medication adherence in outpatients with T2DM.

Assessment of medication adherence in patients with chronic diseases in Tabuk, Kingdom of Saudi Arabia

Kousalya Prabahar; Maymonah Abdullah Albalawi; Sarah Alenizy

Volume 9, Issue 4 , October 2020, , Pages 196-201

Abstract

Uncontrolled chronic diseases such as hypertension and diabetes mellitus can lead to severe complications. Poor adherence to medication is one of the important reasons, leading ... Read More

Pharmacist interventions in improving clinical outcomes in patients with type 2 diabetes mellitus among the underrepresented population: A collaborative ambulatory care pharmacy practice (CAPP) approach

Mok Thoong Chong

Volume 9, Issue 1 , January 2020, , Pages 3-9

Abstract

The objective of this study was to evaluate the impact of pharmacist's interventions through a collaborative ambulatory care pharmacy practice (CAPP) model in patients with type ... Read More

Blood glucose control and opportunities for clinical pharmacists in infectious diseases ward

Minoosh Shabani; Maryam Rashedi; Sareh Razzazzadeh; Ali Saffaei; Zahra Sahraei

Volume 8, Issue 4 , October 2019, , Pages 202-207

Abstract

Increased risk of infection following hyperglycemia has been reported in hospitalized patients. Sliding-scale insulin protocol is an out-of-date method; therefore, it is necessary ... Read More

Impact of pharmacist intervention on appropriate insulin pen use in older patients with type 2 diabetes mellitus in a rural area in Iran

Aida Sefidani Forough; Parsa Riazi Esfahani

Volume 6, Issue 2 , April 2017, , Pages 114-119

Abstract

The aim of this study was to evaluate the impact of pharmacist-conducted educational intervention on reducing errors related to inappropriate insulin pen use.Methods: This ... Read More

Vitamin C may have similar beneficial effects to Gemfibrozil on serum high‑density lipoprotein‑cholesterol in type 2 diabetic patients

. Mansour Siavash; . Masoud Amini

Volume 3, Issue 3 , July 2014, , Pages 77-82

Abstract

Objective: Type 2 diabetes mellitus (DM‑T2) is commonly associated with increased triglycerides (TG), low‑density lipoprotein cholesterol (LDL‑C) and low high‑density lipoprotein ... Read More Objective: Type 2 diabetes mellitus (DM‑T2) is commonly associated with increased triglycerides (TG), low‑density lipoprotein cholesterol (LDL‑C) and low high‑density lipoprotein cholesterol (HDL‑C) levels. Fibrates like gemfibrozil are frequently used in diabetic patients to decrease TG and increase HDL‑C levels. We compared the efficacy of Vitamin C, an antioxidant vitamin, with gemfibrozil on serum HDL‑C in diabetic patients.Methods: Type 2 diabetic patients, referred to our out‑patient clinic were randomly divided into three groups. After 1 month of lifestyle and diet modifications, groupsA, B, and C were prescribed 1000 mg Vitamin C, 600 mg gemfibrozil and combination of both, respectively. Before the study initiation and after 6th week of drug prescription, the blood samples were taken and analyzed for total cholesterol (Total‑C), HDL‑C, TG, fasting blood sugar (FBS), and hemoglobin A1c (HbA1c) levels.Findings: Sixty‑seven patients entered, and 50 patients (18 male, 32 female) finished the study. Overall, serum HDL‑C increased significantly from 39.8 to 45.2 mg/dL in the participants (P = 0.001). HDL‑C increased 6.3, 4.4 and 5.0 mg/dL in groups A, B and C, respectively (related significances were 0.017, 0.022 and 0.033, respectively). Significant decrease of serum TG and Total‑C occurred in gemfibrozil and combination groups, but not in Vitamin C group. Changes in serum HDL‑C between three groups were not significant (P = 0.963). We found a significant decrease in TG and Total‑C in the groups B and C (P < 0.05), but no significant changes of TG, Total‑C, LDL‑C, FBS and HbA1c in group A (P > 0.05).Conclusion: The results demonstrated that Vitamin C may have beneficial effects on HDL‑C in diabetic patients without significant effects on plasma glucose or other lipid parameters; however, its role for the treatment of low HDL‑C patients should be evaluated in larger studies.

Journal of Research in Pharmacy Practice

Articles in Press

Current Issue

Volume 11 (2022)

Volume 10 (2021)

Volume 9 (2020)

Volume 8 (2019)

Volume 7 (2018)

Volume 6 (2017)

Volume 5 (2016)

Volume 4 (2015)

Volume 3 (2014)

Volume 2 (2013)

Volume 1 (2012)

Keywords = Diabetes mellitus

Statin type and cancer outcomes in patients with diabetes type 2 and solid tumors

Abstract

Effect of pharmacist intervention on medication adherence and clinical outcomes of type 2 diabetes mellitus outpatients in primary healthcare in Indonesia

Abstract

Assessment of medication adherence in patients with chronic diseases in Tabuk, Kingdom of Saudi Arabia

Abstract

Pharmacist interventions in improving clinical outcomes in patients with type 2 diabetes mellitus among the underrepresented population: A collaborative ambulatory care pharmacy practice (CAPP) approach

Abstract

Blood glucose control and opportunities for clinical pharmacists in infectious diseases ward

Abstract

Impact of pharmacist intervention on appropriate insulin pen use in older patients with type 2 diabetes mellitus in a rural area in Iran

Abstract

Vitamin C may have similar beneficial effects to Gemfibrozil on serum high‑density lipoprotein‑cholesterol in type 2 diabetic patients

Abstract