. Azim Honarmand; . Mohammadreza Safavi; . Mansoureh Chegeni; . Anahita Hirmanpour; . Masoud Nazem; . Seyyad Hamid Sarizdi
Volume 5, Issue 1 , January 2016, , Pages 16-21
Abstract
Objective: The purpose of the present study was to evaluate the efficacy of midazolam‑ondansetron combination in prevention of postoperative nausea and vomiting (PONV) after ...
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Objective: The purpose of the present study was to evaluate the efficacy of midazolam‑ondansetron combination in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery and its comparison with using midazolam or ondansetron alone.Methods: One hundred and forty patients were enrolled in four groups to receive midazolam 0.75 mg/kg in group M, ondansetron 4 mg in group O, midazolam 0.75 mg/kg and ondansetron 4 mg in group MO, and saline 0.9% in group S intravenously just before anesthesia. Assessment of nausea, vomiting, rescue antiemetic, and side effects of study drugs such as headache and dizziness was carried out postoperatively for 24 h.Findings: The incidence of PONV was significantly smaller in groupMO than groupM and groupO, while there was no significant difference between group M and groupO during the first 24 h postoperatively. Requirement to the additional antiemetic was significantly more in group S (71.4%) compared to other groups, while in group MO (11.4%) was lower than group M (31.4%) and group O (34.3%).Conclusion: Our study showed that prophylactic administration of midazolam 0.75 mg/kg combined with ondansetron 4 mg was more effective than using midazolam or ondansetron alone in prevention of PONV after middle ear surgery.