Journal of Research in Pharmacy Practice

Antibiotic resistance patterns of microorganisms isolated from nephrology and kidney transplant wards of a referral academic hospital

. Atieh Samanipour; . Simin Dashti-Khavidaki; . Mohammad-Reza Abbasi; . Alireza Abdollahi

Volume 5, Issue 1 , January 2016, , Pages 43-51

Abstract

Objective: Antibiotic use pattern and emergence of resistant bacteria are major concerns in clinical settings. This study aimed to detect common bacteria and their antibiotic ... Read More Objective: Antibiotic use pattern and emergence of resistant bacteria are major concerns in clinical settings. This study aimed to detect common bacteria and their antibiotic sensitivity patterns in nephrology and kidney transplant wards.Methods: This 1‑year, observational study was performed in the nephrology and kidney transplant wards of Imam Khomeini Hospital Complex, Tehran, Iran. All patients treated with antimicrobial agents for confirmed or suspected infections were included. Their demographic, clinical, and laboratory data (including biological media used for microbial culture, growth organisms, and antibiograms) were collected. Adherence of antimicrobial regimen to standard guidelines was also assessed.Findings: About half of the patients received antibiotic. The most common infecting bacteria were Escherichia coli followed by Enterococcus sp. and Staphylococcus aureus.E. coli showed high rate of sensitivity to carbapenems and nitrofurantoin and high rate of resistance to co‑trimoxazole and ciprofloxacin. Enterococcus sp. in both wards had high rate of resistance to ampicillin and were all sensitive to linezolid. Unlike to the nephrology ward, more than 50% of Enterococcus sp. from kidney transplant ward was resistant to vancomycin. The most common type of S. aureus in this nephrology ward was methicillin‑resistant S. aureus (MRSA). Most commonly‑prescribed antibiotics were carbapenems followed by vancomycin, ciprofloxacin, and ceftriaxone. Antibiotic regimens were 75% and 83%, 85% and 91%, and 80% and 87% compatible with international guidelines in antibiotic types, dosages, and treatment durations, respectively, in nephrology and kidney transplant wards, respectively.Conclusion: MRSA, fluoroquinolone‑resistant E. coli, and vancomycin resistant Enterococcus species are major threats in nephrology and kidney transplant wards. Most commonly‑prescribed antibiotics were carbapenems that necessitate providing internal guidelines by the teamwork of clinical pharmacist, infectious disease specialists, and nephrologists to avoid the widespread use of broad‑spectrum antibiotics.

Possible unaware intoxication by anticoagulant rodenticide

. Simin Dashti-Khavidaki; . Saba Ghaffari; . Mohsen Nassiri-Toossi; . Mohsen Amini; . Maryam Edalatifard

Volume 3, Issue 4 , October 2014, , Pages 142-144

Abstract

Superwarfarin toxicity may be a serious problem. It needs high clinical suspicious in patients with bleeding diathesis without hematologic or liver diseases even in patients with ... Read More

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Author = . Simin Dashti-Khavidaki

Antibiotic resistance patterns of microorganisms isolated from nephrology and kidney transplant wards of a referral academic hospital

Abstract

Possible unaware intoxication by anticoagulant rodenticide

Abstract