Premedication dilemmas, is Pregabalin the answer?
Volume 4, Issue 3, Summer 2015, Pages 142-146
. Preetha Elizabeth George, . Reetika Chander, . Dootika Liddle, . Valsamma Abraham
Abstract Objective: Laryngoscopy and intubation are associated with sympathetic stimulation which
can prove deleterious in patients with cardiovascular compromise; so, various methods have
been tried to obtund this pressor response. In this study, we have assessed the efficacy of
pregabalin in attenuating the pressor response to laryngoscopy and intubation.
Methods: This prospective randomized study included 80 patients with American Society
of Anesthesiologists physical status grades I‑II, in the age group of 18–60 years of age.
The patients were randomized into two groups of 40 patients each. Group A received
the placebo orally, 90 min prior to surgery. Group B received 150 mg of pregabalin orally,
90 min prior to surgery. These patients were assessed in terms of sedation with Ramsay
sedation scale (RSS). In the operation theatre, the heart rate (HR), systolic blood pressure,
diastolic blood pressure, mean arterial pressure, and oxygen saturation recorded at baseline
and 1, 3, 5, and 10 min after intubation. The rate pressure product (RPP) was calculated for
these time intervals. In the postoperative period, patients were assessed for complications
like dizziness, nausea, and blurred vision. Statistical analysis was performed using Chi‑square
and ANOVA tests.
Findings: The group receiving 150 mg of pregabalin as premedication was found to be
adequately sedated at 1 h post-premedication with 52% patients having a RSS score of 3
compared to 4% with the same RSS score in the placebo group (P < 0.0001). Hemodynamics
was more stable post-intubation with significant stability in the HR (P = 0.002) and
RPP (P = 0.004) in the pregabalin group.
Conclusion: Pregabalin when given as a premedication provides adequate sedation and
obtunds the pressor response seen with intubation.