Journal of Research in Pharmacy Practice

Effect of high‑dose Ascorbic acid on vasopressor’s requirement in septic shock

. Mohadeseh Hosseini Zabet; . Mostafa Mohammadi; . Masoud Ramezani; . Hossein Khalili

Volume 5, Issue 2 , April 2016, , Pages 94-100

Abstract

Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the ... Read More

Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in‑hospital mortality of critically ill surgical patients

. Nafiseh Alizadeh; . Hossein Khalili; . Mostafa Mohammadi; . Alireza Abdollahi

Volume 4, Issue 4 , October 2015, , Pages 193-198

Abstract

Objective: There is few data regarding the correlation between serum Vitamin D level and unfavorable intensive care unit (ICU) outcome in postsurgical patients. In this study, correlation ... Read More Objective: There is few data regarding the correlation between serum Vitamin D level and unfavorable intensive care unit (ICU) outcome in postsurgical patients. In this study, correlation between serum 25(OH)D level and length of ICU stay and in‑hospital mortality has been evaluated in critically ill surgical patients.Methods: Serum 25(OH)D has been evaluated in 70 surgical, critically ill patients. Demographic, laboratory, and clinical data of the patients were collected. Correlation between serum 25(OH) D level and duration of ICU stay and hospital mortality was evaluated using two‑factor analysis of covariance. Multivariable Cox‑regression analysis was used for adjusting the effect of season of blood sampling and type of surgery on the main variables. For all the analyses, P values less than or equal to 0.05 were considered as statistically significant.Findings: Serum 25(OH)D deficiency was identified in 52 (74.3%) of the patients. Patients with serum Vitamin D levels < 30 ng/ml had longer length of ICU stay than those with serum Vitamin D levels ≥ 30 ng/ml (7.8 ± 5.1 vs. 4.05 ± 2.12 days, P = 0.003). Although hospital mortality was more common in Vitamin D deficient patients than sufficient ones (25% in deficient group versus 22.2% in sufficient group), there was no significant difference regarding hospital mortality rate between the groups.Conclusion: Statistically significant association was found between low 25(OH)D level and increased length of ICU stay in critically ill surgical patients. It could be explained by favorable effects of Vitamin D on immune system functions, reducing tissue dysfunction, and risk of organ failure and overall complications. However, there was no correlation between serum Vitamin D level and patients’ in‑hospital mortality. Further, well‑designed prospective clinical studies with adequate sample size are needed to evaluate correlation between serum Vitamin D level and mortality in critically ill patients.

Antibiotic regimens for treatment of infections due to multidrug‑resistant Gram‑negative pathogens: An evidence‑based literature review

. Mandana Izadpanah; . Hossein Khalili

Volume 4, Issue 3 , July 2015, , Pages 105-114

Abstract

Evidences regarding the efficacy of different antibiotic regimens proposed for treatment of multidrug‑resistant (MDR) Gram‑negative pathogens have been reviewed. Available ... Read More

Adverse reactions of Methylphenidate in children with attention deficit‑hyperactivity disorder: Report from a referral center

. Zahra Khajehpiri; . Javad Mahmoudi-Gharaei; . Toktam Faghihi; . Iman Karimzadeh; . Hossein Khalili; . Mostafa Mohammadi

Volume 3, Issue 4 , October 2014, , Pages 130-136

Abstract

Objective: The aim of the current study was to determine various aspects of methylphenidate adverse reactions in children with attention deficit‑hyperactivity disorder (ADHD) ... Read More

Double-disk synergy test for detection of synergistic effect between antibiotics against nosocomial strains of staphylococcus aureus

. Rasool Soltani; . Hossein Khalili; . Fateme Shafiee

Volume 1, Issue 1 , August 2012, , Pages 21-24

Abstract

Objective: Synergistic effect between commonly used antibiotics against nosocomial multidrug-resistant strains of Staphylococcus aureus, if present, could provide a viable option ... Read More

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Author = . Hossein Khalili

Effect of high‑dose Ascorbic acid on vasopressor’s requirement in septic shock

Abstract

Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in‑hospital mortality of critically ill surgical patients

Abstract

Antibiotic regimens for treatment of infections due to multidrug‑resistant Gram‑negative pathogens: An evidence‑based literature review

Abstract

Adverse reactions of Methylphenidate in children with attention deficit‑hyperactivity disorder: Report from a referral center

Abstract

Double-disk synergy test for detection of synergistic effect between antibiotics against nosocomial strains of staphylococcus aureus

Abstract